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There was no difference in the outcome between women who were assigned to letrozole alone and those who were assigned to letrozole followed by tamoxifen, regardless of nodal status ().

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Phase III study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: analysis of survival and update of efficacy from the International Letrozole Breast Cancer Group.

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This trial supports consideration of adjuvant chemotherapy after complete resection of isolated locoregional recurrence of breast cancer.

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